Immunophenotypical characterization of paraneoplastic neurological syndrome patients: a multicentric study

Paraneoplastic neurological syndromes (PNS) are a group of rare and severe immune-mediated disorders that affect the nervous system in patients with cancer. The best way to diagnose paraneoplastic disorder is identify anti-onconeural protein antibodies specifically associated various cancers. aim this multicentric study was clinically immunologically characterize PNS their association Patients suspected have were enrolled from clinical centres characterized immunologically. This population consisted 112 patients. Onset mainly subacute (76%). had symptoms. developed before diagnosis cancer 28 definite six most frequent autoantibodies detected anti-Hu anti-Yo. One patient cerebellar syndrome anti-Tr antibody seven atypical antibodies. literature associates these Our observations confirm important role importance for early